CRC Press Recent Advancement in Prodrugs

Recent Advancement in Prodrugs Drugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations. Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field. About the Author Dr. Kamal Shah did his graduation from Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal (MP) and also awarded by Chancellor Gold Medal and Smt. Kamla Chaturvedi Memorial Award for securing 1st position in Graduation (B.Pharma). He has qualified GATE 2003 and GATE 2005 (IIT, Mumbai). In the year 2006, He did his Masters from Dr. H.S. Gour University Sagar and worked on method development for determination of pharmacological active components by UV and HPLC. He has completed his doctorate from Dr. APJ Abdul Kalam Technical University, Lucknow. Currently he is working as Associate Professor in Institute of Pharmaceutical Research, GLA University Mathura (U.P.). He has published his research work in various journals of national and international repute, and has total 30 published research papers to his credit and has more than 300 citations. He is a member of various professional and academic bodies like Association of Pharmaceutical Teachers of India (APTI), Institutional animal ethical committee (IAEC) and Board of Studies (BOS). He is reviewer of various National and International journals like Medicinal Chemistry Research, Pakistan Journal of Pharmaceutical Sciences, Journal of Sexual Medicine, Natural Product Research, African Journal of Pharmacy and Pharmacology, International Journal of Pharmacy and Pharmacology, International Research Journal of Pure and Applied Chemistry, Pharmaceutical Biology and Asian Journal of Pharmaceutics. He has also written 6 chapters and Edited 1 book. His area of interest is “Synthesis and evaluation of prodrugs of NSAIDs”. Durgesh Nandini Chauhan completed her B.Pharm degree in Pharmacy from the Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, India and her M.Pharma (pharmaceutical sciences) in pharmaceutics from Uttar Pradesh Technical University,currently Dr. A.P.J. Abdul Kalam Technical University, Lucknow in 2006. Mrs. Durgesh Nandini Chauhan has 10 years of academic (teaching) experience from Institutes of India in pharmaceutical sciences. She taught subjects as pharmaceutics, pharmacognosy, traditional concepts of medicinal plants, drug-delivery phytochemistry, cosmetic technology, pharmaceutical engineering, pharmaceutical packaging, quality assurance, dosage form designing and anatomy and physiology. She is member of Association of Pharmaceutical Teachers of India,SILAE: Società Italo-Latinoamericana di Etnomedicina (The Scientific Network on Ethnomedicine, Italy), and so forth. Her previous research work included “Penetration Enhancement Studies on Organogel of Oxytetracycline HCL.” She also attended AICTE-sponsored Staff Development Program on “Effects of Teaching and Learning Skills in Pharmacy-Tool for Improvement of Young Pharmacy Teachers” and workshop on Analytical Instruments. She has written more than 10 publications in national and international journals, 13 book chapters, and authored in 4 books .She is also active as a reviewer for several in