Academic Press Autophagy and Metabolism: Potential Target for Cancer Therapy

Autophagy and Metabolism: Potential Target for Cancer Therapy presents updated knowledge about the role of autophagy in cancer metabolism and how it can be used to develop new and more efficient treatments. Written by leading experts in the field, it presents information from recent research and explains how to translate it to the clinical setting. The book discusses topics such as tumor cell metabolism and autophagy as therapeutic targets; autophagy regulation in cancer; signaling pathways in metabolic dysregulation in solid tumors; metabolic stress and cell death pathways; and the role of tumor microenvironment. In addition, it covers combined targeting autophagy and metabolism for cancer therapy and the effect of autophagy on immune cell metabolism. It is a valuable resource for researchers, oncologists, graduate students, and members of biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism. From the Back Cover <p><i>Autophagy and Metabolism: Potential Target for Cancer Therapy</i> presents updated knowledge about the role of autophagy in cancer metabolism and how it can be used to develop new and more efficient treatments. Written by leading experts in the field, it presents information from recent research and explains how to translate it to the clinical setting.</p> <p>The book discusses topics such as tumor cell metabolism and autophagy as therapeutic targets; autophagy regulation in cancer; signaling pathways in metabolic dysregulation in solid tumors; metabolic stress and cell death pathways; and the role of tumor microenvironment. In addition, it covers combined targeting autophagy and metabolism for cancer therapy and the effect of autophagy on immune cell metabolism.</p> <p>It is a valuable resource for researchers, oncologists, graduate students, and members of biomedical field who are interested in learning more about the interaction between autophagy and cancer metabolism.</p> About the Author Prof. Dhruv Kumar is a Professor at Amity Institute of Molecular Medicine & Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh (AUUP), Noida, and his current research is focused on autophagy, cancer cell metabolism, tumour microenvironment, exosomes, mutational heterogeneity, cancer prevention, drug designing, NGS and COVID-19. After completion of B.Sc. in Chemistry from Banaras Hindu University (BHU) and M.Sc. in Bioinformatics from University of Allahabad, India, he has completed his Ph.D. in Cellular, Molecular and Industrial Biology from the University of Bologna (UNIBO), under highly prestigious fellowship, Indo-Italian Government fellowship. After his Ph.D., he obtained Postdoctoral training at the University of Kansas Medical Center, USA. During his Postdoctoral training, he worked towards understanding the molecular mechanism(s) of autophagy regulation and apoptosis in cancer stem cells (prostate, pancreatic and breast), focusing on the metabolic cross-talk between the tumour microenvironment (cancer associated fibroblast (CAF)) and head and neck squamous cell carcinoma (HNSCC) via HGF/c-MET and bFGF/FGFR signalling pathways. He has also worked on structure based drug designing for several cancers, COVID-19, mutational heterogeneity in cancer. Currently, his lab is focusing on metabolic heterogeneity in solid tumours and structure based drug designing for cancer and COVID-19. He has published more than 80 research articles, reviews and book chapters in reputed journals. Shailendra Asthana is a Senior Scientist at Translational Health Science and Technology Institute (THSTI), India. He has more than 20 years of research experience in drug discovery, autophagy, and bioinformatics. The goal of his research is to improve atomic level understanding of protein-ligand, protein-nucleic acid, protein-peptide and protein-protein interactions using computational models and tools. Using molecular modeling,