Macrophages in the Human Body: A Tissue Level Approach

Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions. Macrophages in the Human Body: A Tissue Level Approach presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential. Review Approaches the aspects of the different macrophages present in different tissues of the body From the Back Cover Through recent research, there has been a significant number of findings involving the biology of macrophages. Beyond the 1st line of defense, macrophages have several specific characteristics across different tissues, organs, and systems. Macrophages comprehend a heterogeneous phagocytic population with wide range phenotypes, and tissue-specific functions, such as bone resorption, extracellular matrix production, red blood cells and bacteria removal, among others. Through innate immune receptors macrophages can modulate several pathways that culminate in the production of various types of inflammatory mediators such as chemokines, cytokines, oxygen reactive species, and lipid mediators which ultimately altered the behavior of other cells. Moreover, environment signals modify and induce metabolic reprograming that it alters phenotype and functions.<br><br><i>Macrophages in the Human Body: A Tissue Level Approach</i> presents a current overview of the diversity of macrophages across multiple human body systems, their phenotype, function and metabolic characteristics. It covers translational aspects where there is research support to indicate the therapeutic potential. About the Author Dr. Niels Olson Sairava Camara: Currently full professor of Department of Immunology at the Institute of Biomedical Sciences at the University of São Paulo (since 2011). Visiting Professor at the University of Tours, France in 2006. His laboratory has experience in nephrology area and in cellular and applied immunology, acting on the following topics: kidney transplantation, experimental models of acute and chronic kidney diseases, ischemia and reperfusion injury, regulatory cells and stem cells in kidney diseases. More recently, the laboratory has been studying the microbiota interface, cellular metabolism and inflammation in models of autoimmunity. Dr. Tárcio Teodoro Braga is currently Professor of Immunology in the Department of Pathology at the Federal University of Parana-UFPR (since 2018). Permanent Professor in the Graduate Courses in Microbiology, Parasitology and Pathology at UFPR and in Biosciences and Biotechnology at the Carlos Chagas Institute, Fiocruz PR. Concluded the Biomedical course at the Federal University of Triângulo Mineiro. He holds a PhD in Sciences from the Department of Immunology of the University of Sao Paulo-USP, with a sandwich period at the University of Maryland and at the University of California, San Francisco. He completed his postdoctoral studies at USP, with an internship at the University of Bonn, Germany, and another postdoctoral fellowship at the Federal University of Sao Paul