Academic Press Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy ... Agents for Chemotherapy, Volume 7)

Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Review "The therapeutic success of antineoplastic drugs is a challenge due to the development of chemoresistance by the cancer cells. An understanding of the mechanism of chemoresistance and chemo-sensitization is critical to improving cancer treatment outcomes. Contributed by many experts around the world, this book offers up-to-date information on the efflux transporters and possible strategies to inhibit the efflux pumps in cancer cells. There are several books in the marketplace related to chemoresistance and chemo-sensitization. This book, however, focuses on the mechanistic approach to characterization and inhibition of efflux transporters. Thus, it is expected to be well received by the scientists working in this field of study." --Doody Review Describes fundamental aspects of efflux pumps of the ATP-binding cassette superfamily, along with strategies to target and improve chemotherapy efficacy From the Back Cover Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition to Inhibition Strategies in Chemotherapy describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways and the strategies to target them and improve chemotherapy efficacy.Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure, regardless of the inherent efficacy of the chemotherapy. In this book, the approach is discussed for different cancer types, such as breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium describing the involvement of the efflux pumps in mechanisms of cancer resistance. About the Author Dr. Alejandro Sosnik received his Pharmacy degree from the Faculty of Pharmacy and Biochemistry of the University of Buenos Aires in 1994, after two years as junior research scholar of the University of Buenos Aires in the field of organic chemistry (1993-1995). In early 1997, he moved to Israel where after obtaining the pharmacist license, he continued his graduate studies, receiving PhD in applied chemistry (polymeric biomaterials) from the Casali Institute of Applied Chemistry (The Hebrew University of Jerusalem, Israel, 2003) under the supervision of Dr.Daniel Cohn. In 2003-6, Dr.Sosnik undertook postdoctoral training in the laboratory of Professor Michael Sefton (Institute of Chemical Engineering and Applied Chemistry/Institute of Biomaterials and Biomedical Engineering, University of Toronto, Canada