Academic Press Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery covers recent developments in tumor model systems for translational cancer research. Virtually all types of existing and emerging tumor models in use by the research community are discussed. Areas covered include the latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. Chapters on larger animal models, canine models and their use in pre-IND development make this a unique volume. In addition, sections on breeding methodologies and handling and assessment procedures make this book a must read. This book will be a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations and knowledge seekers at all levels of the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid system, humanized and other models in modern biology paradigms Covers the use of these models in personalized medicine, immunotherapy, toxicology, Pre-IN assessments and related drug development arenas Presents protocols, procedures and a comprehensive glossary to help newer readers understand technical terms and specialized nomenclature Review Presents cutting-edge tumor model advancements that are aiding drug discovery, including up-to-date information on patient derived xenografts From the Back Cover Animal Models in Cancer Drug Discovery Edited by Asfar Azmi and Ramzi M. Mohammad Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Key Features Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid system, humanized and other models in modern biology paradigms that are enhancing research in drug discovery field Covers the use of these models in personalized medicine, immunotherapy, toxicology, Pre-IN assesments and related drug development arenas Presents protocols, procedures and a comprehensive glossary to help newer readers understand technical terms and specialized nomenclature About the Editors: Asfar Azmi, PhD, is an Assistant Professor at the Department of Oncology, Wayne State University. He has more than a decade of research experience in the area of cancer biology and drug discovery. Dr. Azmis lab has made significant pre-clinical discoveries in advanced animal tumor models that helped the clinical development of new cancer drugs. Dr. Azmi has considerable experience in the area of early phase clinical research. Several agents developed by his team have gone into Phase II clinical studies. He has published more than 100 cancer research articles and has edited three additional books, among which there are the Elsevier p