Elsevier Comprehensive Medicinal Chemistry II, Volume 5: ADME-TOX APPROACHES

Product Description To be effective a drug must be Absorbed then Distributed to the site of action. It must also be Metabolised and Excreted without any measurable Toxicity (ADMET). This volume examines major ADMET issues, tools to measure these properties in vivo and in vitro and in-silico tools to predict and analyse effects. It concludes with a review of tools that can assist drug discovery in its early development stage. * valuable content available May 2009 as an individual volume * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience * priced for individual researcher as well as library purchase Review Now available as individual volumes -- this volume reviews techniques for measuring, modelling and improving Absorption, Distribution, Metabolism, Excretion and Toxicity of drugs