£131.36

Springer Mirror-Image Protein Therapeutics Doctoral Thesis - Springer

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Description

This doctoral thesis from Kyoto University explores the chemical synthesis and functional characterisation of protein domains for developing mirror-image therapeutics with reduced immunogenicity. The research focuses on preparing and evaluating therapeutic protein domains, including the extracellular domain of T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), and human serum albumin domain III. By examining the bioactivities and functions of these synthetic protein domains, the thesis demonstrates how mirror-image protein therapeutics can be developed through chemical synthesis methods. This work represents a significant contribution to protein engineering and therapeutic development, offering insights into strategies for creating more effective and safer protein-based treatments with lower immunogenic responses.

Key Features

The thesis presents chemical synthesis methods for protein domains of therapeutic importance used in mirror-image protein therapeutic development.

Focuses on functional evaluations of TIGIT extracellular domain and human serum albumin domain III, two key therapeutic target proteins.

Demonstrates how mirror-image protein domains can reduce immunogenicity compared to conventional protein therapeutics through synthetic approaches.

Accepted as a doctoral thesis by Kyoto University, providing peer-reviewed academic research on protein domain preparation and characterisation.

Published by Springer as part of the Springer Theses series, ensuring scholarly credibility and accessibility to researchers in protein engineering.

Covers bioactivity assessments and functional studies essential for understanding therapeutic efficacy of synthetic protein domains.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
03 February 2026
Listed Since
30 October 2025

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