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Springer Prokaryotic Toxin-Antitoxins - Research Overview

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Description

Explore the rapidly expanding field of microbiology with Prokaryotic Toxins - Antitoxins by Springer. This comprehensive text provides the first major overview of toxin-antitoxin (TA) genes, which were first identified on plasmids three decades ago. Since that discovery, research has shown that these genes are highly abundant across both bacterial and archaeal chromosomes. This book explains the fundamental mechanics of how TA genes function. The genes code for an antitoxin that binds with and neutralizes a specific cognate toxin. When these systems are activated, the toxins inhibit protein synthesis and cell growth. This process induces dormancy and multidrug tolerance, also known as persistence, in various microorganisms. Readers will learn about the dramatic expansions of TA gene families observed in certain species. This resource is essential for researchers and professionals looking to understand the biological mechanisms that drive bacterial survival and resistance. It offers a deep look into a specialized area of pathology and microbiology that continues to shape modern scientific understanding.

Key Features

Provides a foundational overview of the expanding research field surrounding toxin-antitoxin (TA) genes.

Details the discovery and evolution of TA genes from plasmids to widespread presence in bacterial and archaeal chromosomes.

Explains the biological mechanism where antitoxins neutralize cognate toxins to regulate cell functions.

Covers how toxin activation leads to inhibited protein synthesis, cell growth, and induced dormancy.

Discusses the role of TA systems in driving multidrug tolerance and microbial persistence.

Examines the dramatic expansion of TA gene families within specific microbial species.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
09 November 2014
Listed Since
05 November 2014

Barcode

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