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Springer Polyploidization and Cancer: Advances in Experimental Medicine

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Description

Explore the critical relationship between polyploidization and cancer development in this comprehensive volume from Springer's Advances in Experimental Medicine and Biology series. This book examines how limiting genome replication to once per cell cycle is essential for maintaining genome stability, whilst inappropriate polyploidization can promote aneuploidy and cellular transformation. Learn how surveillance mechanisms that normally prevent polyploidization become disrupted in cancer cells, and discover the underlying principles that govern genome stability. Leading experts in the field provide an authoritative overview of current research into how polyploidization contributes to cancer progression and what strategies may prevent these critical cellular changes.

Key Features

Part of Springer's Advances in Experimental Medicine and Biology series, volume 676, providing peer-reviewed research on polyploidization mechanisms.

Addresses how genome replication control prevents aneuploidy and explores why this control fails in cancer cells.

Compiled by leading researchers who examine surveillance mechanisms and their perturbation in malignant transformation.

Covers the physiological importance of polyploidization in specialised cell types alongside its role in cancer development.

Provides comprehensive overview of recent progress in understanding genome stability principles and cancer prevention strategies.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
21 May 2010
Listed Since
26 February 2010

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