£106.77

Springer - Novel Developments in Stem Cell Mobilization

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Description

Explore the latest scientific advancements in hematopoietic stem cell research with this specialized volume from Springer. This text examines the CXCR4/CXCL12-axis, a key adhesion pathway that governs how stem cells are retained within the bone marrow. By understanding these mechanisms, researchers can better approach the development of effective antagonists. The book covers the pharmacology research that leads to the rational development of these agents. It specifically highlights plerixafor, a clinically approved antagonist used for stem cell mobilization in patients with lymphoma and myeloma. This mobilization is a vital step that enables patients to receive life-saving treatments that would otherwise be impossible to administer. This resource provides essential insights for medical professionals and researchers working in oncology and hematology.

Key Features

Examines the CXCR4/CXCL12-axis and its role in hematopoietic stem cell retention within the bone marrow.

Provides insights into the pharmacology research required for the rational development of effective antagonists.

Covers the clinical application of plerixafor for stem cell mobilization in lymphoma and myeloma patients.

Discusses how stem cell mobilization enables life-saving medical treatments for specific patient populations.

Offers detailed information on the development of CXCR4 antagonists with different chemical specifications.

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