£102.53

Springer - Human Immunodeficiency Virus Reverse Transcriptase

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Description

Explore the history and scientific progress of one of the most studied retroviral enzymes. This text covers the development of HIV-1 Reverse Transcriptase (RT) from early heterologous expression and purification in the 1980s to modern medicinal breakthroughs. Readers will follow the timeline of HIV-1 research, including the 1987 approval of the first nucleoside analogue RT inhibitor (NRTI) and the 1996 approval of the first non-nucleoside analogue RT inhibitor (NNRTI). The content also addresses the discovery of resistance to RT inhibitors and the various crystal structures of RT with and without bound substrates or inhibitors. This resource provides a detailed look at the milestones that bridge laboratory research with clinical application. It is a valuable reference for those studying immunology, internal medicine, and the evolution of retroviral enzyme studies.

Key Features

Detailed history of HIV-1 RT research starting from early expression and purification in the eighties.

Coverage of major pharmaceutical milestones including the approval of NRTIs and NNRTIs.

Analysis of the discovery of resistance to various RT inhibitors.

Scientific discussion regarding crystal structures of RT with bound substrates and inhibitors.

Comprehensive look at the transition from bench research to clinical bedside applications.

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