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Springer DNA Methylation, Epigenetics and Metastasis - Cancer Biology

Amazon

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Description

This comprehensive volume explores the molecular mechanisms driving cancer metastasis, focusing on DNA methylation and epigenetic regulation in tumour cell dissemination. The book examines how transformed cells detach from primary sites, invade surrounding tissues and migrate through the bloodstream to establish secondary tumours at distant locations. Researchers will discover detailed analysis of key genes involved in metastatic processes, including cadherins, laminins, heparan sulfates and protease inhibitors that control angiogenesis and tumour spread. The text addresses the paradox of limited genetic alterations in these metastasis-related genes despite their central role in human cancers, offering insights into epigenetic modifications that drive malignant progression without obvious DNA sequence changes. Part of the Cancer Metastasis - Biology and Treatment series, this volume provides essential reading for oncologists, cancer researchers and medical professionals seeking to understand the molecular basis of metastatic disease and potential therapeutic targets.

Key Features

Examines DNA methylation and epigenetic mechanisms controlling cancer cell detachment, invasion and bloodstream dissemination.

Analyses cadherins, laminins and heparan sulfates as key regulators of tumour metastasis and cell-cell adhesion.

Investigates protease inhibitors and angiogenesis factors that suppress or promote metastatic spread in human cancers.

Addresses the genetic paradox of limited alterations in metastasis genes despite their frequent involvement in tumour progression.

Published by Springer as part 7 of the Cancer Metastasis - Biology and Treatment comprehensive series.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
09 June 2005
Listed Since
30 December 2006

Barcode

No barcode data available

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