Springer Cardiac Fibrosis and Heart Failure - Biochemistry Book

Explore the complex biological mechanisms of cardiac fibrosis and heart failure in this academic volume from Springer. Part of the Advances in Biochemistry in Health and Disease series, this book examines the unique biology of cardiac fibroblasts, cardiac myofibroblasts, and valvular interstitial cells. These cells possess distinct characteristics that separate them from other fibroblastic cells, a concept gaining wider recognition in medical research. This collection of articles addresses the molecular processes that control the synthesis and secretion of the cardiac extracellular matrix (ECM). Readers will find detailed discussions regarding the natural signals that stimulate or inhibit cardiac fibrosis. A major focus of the text includes the role of Transforming Growth Factor beta (TGF-beta), an important fibrogenic factor in these processes. This book serves as a specialized resource for understanding how these cellular changes contribute to heart disease and the broader implications for cardiovascular health.