Springer - Bioinformatics for High Throughput Sequencing

Next generation sequencing is transforming the field of molecular biology by allowing researchers to conduct a wide variety of experiments with high speed and low cost. This book addresses the challenges presented by the massive amount of data generated through these modern technologies. As researchers produce gigabases of sequence information in just a few days, the need for effective bioinformatics applications becomes essential. This text covers a broad range of applications, including the sequencing of whole genomes, transcriptomes, and small non-coding RNAs. It also explores the identification of methylated regions, protein-DNA interaction sites, and the detection of structural variation. Designed for those working within the high bandwidth of modern genomic research, this resource provides insight into the computational methods required to manage and interpret the vast data sets produced by next generation sequencing technologies.