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Humana Computational Methods for GPCR Drug Discovery - Methods in Molecular Biology

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Description

This comprehensive volume explores modern computational strategies essential for GPCR drug discovery, covering both structure and ligand-based approaches alongside cheminformatics techniques. The book guides researchers through applying these methods to critical drug discovery challenges, including receptor structure modelling, function and dynamics analysis, prediction of protein-water-ligand interactions, binding kinetics determination, and free energy calculations. It addresses key topics such as agonist and antagonist interconversion, GPCR deorphanization, and the discovery of biased and allosteric modulators. Part of the respected Methods in Molecular Biology series (volume 1705), this resource combines theoretical foundations with practical applications for pharmacologists, computational chemists, and drug discovery professionals seeking to leverage computational tools in their research.

Key Features

Covers structure and ligand-based computational approaches for GPCR drug discovery research.

Includes cheminformatics techniques for addressing key receptor modelling and dynamics challenges.

Describes methods for predicting protein-water-ligand interactions and calculating binding kinetics.

Explores deorphanization strategies and discovery of biased and allosteric GPCR modulators.

Published by Humana as part of the Methods in Molecular Biology 1705 series.

Product Specifications

Brand
Humana
Format
hardcover
Domain
Amazon UK
Release Date
30 November 2017
Listed Since
10 August 2017

Barcode

No barcode data available

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