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CRC Press Handbook of Mitochondrial Dysfunction - CRC Press

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Description

Mitochondria are essential to cellular health, yet dysfunction in these organelles underlies more than 80 human diseases and syndromes. This comprehensive handbook from CRC Press examines the critical role mitochondrial dysfunction plays in disease pathology and aging. The book explores how accumulation of mitochondrial DNA damage leads to dysfunction through two primary pathways: mutations in mitochondrial DNA cause conditions such as Kearns-Sayre syndrome and Pearson syndrome, whilst mutations in chromosomal DNA trigger additional disease states. Understanding mitochondrial function is vital for medical practitioners, neurology specialists, and healthcare professionals working in internal medicine. This authoritative reference provides essential knowledge for clinicians and researchers investigating the mechanisms linking mitochondrial health to human disease, offering insights into prevention, diagnosis, and management strategies.

Key Features

CRC Press handbook covers mitochondrial dysfunction in more than 80 associated human diseases and syndromes.

Detailed examination of how mitochondrial DNA damage accumulation causes disease through dual pathways of mutation.

Explores Kearns-Sayre syndrome, Pearson syndrome, and other mitochondrial-linked conditions affecting neurological health.

Essential resource for neurology, internal medicine, and clinical neurophysiology practitioners and researchers.

Authoritative reference connecting mitochondrial function to aging, disease progression, and cellular health outcomes.

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