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Autoimmune Encephalitis: Contemporary Diagnostic and Therapeutic Strategies: A Stepwise Clinical Guide to Biomarkers, Diagnostics, Treatment Pathways, Red Flags, and Immunotherapy

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Description

Autoimmune encephalitis represents a rapidly evolving category of immune-mediated disorders of the central nervous system in which early recognition and timely intervention are critical determinants of outcome. Characterized by subacute neuropsychiatric symptoms, seizures, cognitive dysfunction, and autonomic instability, these conditions are frequently misdiagnosed as primary psychiatric, infectious, or degenerative disorders. This textbook addresses the diagnostic and therapeutic complexity of autoimmune encephalitis by providing a structured, evidence-based clinical framework designed to support accurate diagnosis and effective management in contemporary practice. The text integrates current understanding of neuroimmunologic mechanisms with practical diagnostic strategies, emphasizing the interpretation of clinical red flags, cerebrospinal fluid findings, autoantibody testing, neuroimaging, and electroencephalography. Particular attention is given to antibody-mediated and antibody-negative syndromes, diagnostic pitfalls, and the limitations of existing biomarkers. Through stepwise clinical reasoning, the book guides clinicians from initial suspicion through confirmation of diagnosis, ensuring timely initiation of immunotherapy while excluding important mimics. Management strategies are presented in a systematic, algorithm-driven manner, encompassing first-line and escalation immunotherapies, tumor-directed treatment in paraneoplastic disease, and supportive care in acute and intensive care settings. The text further addresses seizure management, psychiatric manifestations, autonomic complications, and multidisciplinary coordination, highlighting the importance of early treatment in optimizing neurological recovery. Long-term outcomes, relapse risk, and maintenance immunosuppression are examined to support sustained disease control and functional recovery. By combining pathophysiologic insight with pragmatic clinical guidance, this book serves as a comprehensive reference for clinicians involved in the diagnosis, treatment, and long-term management of autoimmune encephalitis, and as a foundational resource for postgraduate training in neuroimmunology and clinical neurology.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
03 January 2026
Listed Since
03 January 2026

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