£220.00

Taylor & Francis Pharmaceutical Biocatalysis: Chemoenzymatic Synthesis of Active Pharmaceutical Ingredients

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£324.31 £115.89 £161.37 £206.84 £252.31 £297.78 £343.26 09 June 2024 01 November 2024 26 March 2025 18 August 2025 10 January 2026

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108 days 16 days 247 days · current 194 days 16 days 0 62 124 185 247 £135-173 £173-211 £211-249 £249-286 £286-324 Days at Price

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Most common range: £211-249 (247 days, 42.5%)

Price range: £135 - £324

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Description

This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.

Product Specifications

Format
hardcover
Domain
Amazon UK
Release Date
20 December 2019
Listed Since
15 June 2019

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