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£67.85

World Scientific Publishing Company MIF: A MOST INTERESTING FACTOR

Name: MIF: A MOST INTERESTING FACTOR
Brand: World Scientific Publishing Company
Price: 67.85 GBP
Availability: InStock

Immunology

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Description

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development.

Product Specifications

Brand: World Scientific Publishing Company
Format: hardcover
ASIN: 9812706488
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Immunology
Domain: Amazon UK
Release Date: 27 September 2007
Listed Since: 04 April 2007

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World Scientific Publishing Company MIF: A MOST INTERESTING FACTOR

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