Modulation of Oxidative Stress in Heart Disease

This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions. From the Back Cover This book highlights the multifaceted roles of Reactive Oxygen Species (ROS) in modulating normal cellular and molecular mechanisms during the development of different types of heart disease. Each chapter in the book deals with the role that altered redox homeostasis plays in the pathophysiology of heart disease. In addition, the book explains how reactive oxidant species interact with their targets and provides novel strategies for attenuating oxidative stress-induced types of heart disease. The book not only covers ROS-induced response in heart disease at the cellular level, but also demonstrates that an imbalance of redox states has its roots in our genes, and explains the ways gene expression is regulated. In turn, it reviews potential sources of ROS, their pathological effects on the heart, and potential sites for therapeutic interventions. About the Author Dr Sajal Chakraborti is a Professor of Biochemistry at the University of Kalyani, West Bengal, India. He completed his PhD at Calcutta University, Kolkata, India and his DSc at the University of Kalyani. He also pursued postdoctoral research at Johns Hopkins University, Baltimore; University of Utah, Salt Lake City; and New York Medical College, New York as a Fulbright Fellow. He visited the University of Florida, Gainesville, Florida, where he conducted research on f beta-adrenergic receptor activation in heart disease.  His research mainly deals with the role of vasoactive agents in regulating vascular tone under oxidant and calcium signaling phenomena. He has been engaged in biochemistry teaching and research for the past 40 years (email: saj_chakra@rediffmail.com).  Dr Naranjan S Dhalla is a Distinguished Professor at the University of Manitoba, Winnipeg, Canada. His expertise includes the subcellular and molecular basis of heart function in health and disease. He has been engaged in multidisciplinary cardiology research and education for over 50 years. He is currently the Editor-in-chief of Molecular and Cellular Biochemistry (Springer) (email: NSDhalla@sbrc.ca).  Dr Madhu Dixit is a National Chair Fellow of the Translational Health Science and Technology Institute, Faridabad, Haryana, India. She has contributed to the general area of biochemical pharmacology with a special interest in cardiovascular pharmacology and redox biology. Dr Dixit has been engaged in research, especially on drug discovery and development, for over 40 years (email: rmadhudikshit@gmail.com). Dr Nirmal K Ganguly, a distinguished biotechnologist and former Director General of the Indian Council of Medical Research (ICMR), is associated with Global Health Strategies, New Delhi, India. One important aspect of his research is the understanding of occupational, environmental and nutritional aspects of heart disease.  In 2008 he was presented with the Padma Bhushan Award in the field of “Medicine” by the President of India (email: ganguly1nk@gmail.com).