Compact Kernel Of A Metabolic Flux Balance Solution Space, The: Concepts, Algorithms And Implementation - Image 1

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World Scientific Publishing Company Compact Kernel Of A Metabolic Flux Balance Solution Space, The: Concepts, Algorithms And Implementation

Name: Compact Kernel Of A Metabolic Flux Balance Solution Space, The: Concepts, Algorithms And Implementation
Brand: World Scientific Publishing Company
Price: 72.0 GBP
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General Medical Issues

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Description

This monograph offers a fundamentally new approach to facilitate the study of metabolic networks in cells. It aims to overcome the limitations of either just a single FBA solution, or an overwhelming number of extreme pathways in a realistic network. Instead it focusses on the FBA solution space and describes it in a simplified way by extracting just a bounded subspace: the Solution Space Kernel or SSK. This reduces the relevant number of flux space dimensions by orders of magnitude, and allows its location, size and shape to be characterised. It is a multi-stage process, requiring many new concepts and algorithms for manipulating polytopes in high dimensional spaces. The book introduces and develops these concepts in a pragmatic way that takes into account the difficulties of performing analyses in a flux space with dimensions counting in the hundreds or thousands. It emphasizes the details of implementation in computational code and applications to realistic models are demonstrated. For many cases, the number of constraints and flux variables that fully specify the SSK polytope is only a single or double-digit number. This allows the range of metabolic states accessible to a cell to be further interpreted geometrically in terms of a manageable set of orthogonal diameters and aspect ratios. In addition, explicit representative fluxes, giving the centre and periphery of the solution space kernel, become available for further exploration.

Product Specifications

Brand: World Scientific Publishing Company
Format: hardcover
ASIN: 9811255830
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > General Medical Issues
Domain: Amazon UK
Release Date: 23 September 2022
Listed Since: 09 February 2022

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World Scientific Publishing Company Compact Kernel Of A Metabolic Flux Balance Solution Space, The: Concepts, Algorithms And Implementation

About as cheap as it gets. The only time it was cheaper was 11 months ago.

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