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IntechOpen New Developments in the Pathogenesis of Rheumatoid Arthritis

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Description
The pathogenesis of rheumatoid arthritis (Ra) is incompletely understood. Hla class Ii alleles and T cells have been implicated for many years. The discovery of anticitrullinated peptide antibodies (Acpas), along with the effectiveness of biological treatments targeting cytokines, such as Tnf-?, Il-6, and also T cells and B cells, reinforced the pathogenetic role of the respective factors. Acpas, induced by cigarette smoking and periodontitis in individuals with Hla-Drb1 shared epitope, appear to be autoantigens that initiate the inflammatory immune response in Ra. MicroRnas, part of epigenetic mechanisms, which also include Dna methylation, and histone modification, as well as microbiota, the composition of microbes in body cavities, also appear to influence arthritis and are discussed in this book.

Product Specifications
Brand
IntechOpen
Format
paperback
ASIN
9535129694
Category
Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Internal Medicine > Diseases & Disorders > Immunology
Domain
Amazon UK
Release Date
22 February 2017
Listed Since
06 September 2017

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