Springer Aminoacyl-tRNA Synthetases in Biology and Medicine: 344 (Topics in Current Chemistry, 344)

This book will focus on new molecular interactions and novel activities and the associated diseases that have been recently discovered from the studies of eukaryotic and mammalian aminoacyl-tRNA synthetases. In addition, the potential applications of ARS researches in biotechnology and medicine will be addressed. From the Back Cover 1 Synthetic and Editing Mechanisms of Aminoacyl-tRNA Synthetases John J. Perona, Ita Gruic-Sovulj 2 Emergence and Evolution Tammy J. Bullwinkle, Michael Ibba 3 Architecture and Metamorphosis Min Guo, Xiang-Lei Yang 4 Protein–Protein Interactions and Multi-component Complexes of Aminoacyl-tRNA Synthetases Jong Hyun Kim, Jung Min Han, Sunghoon Kim 5 Extracellular Activities of Aminoacyl-tRNA Synthetases: New Mediators for Cell–Cell Communication Sung Hwa Son, Min Chul Park, and Sunghoon Kim 6. Non-catalytic Regulation of Gene Expression by Aminoacyl-tRNA Synthetases Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox 7 Amino-Acyl tRNA Synthetases Generate Dinucleotide Polyphosphates as Second Messengers: Functional Implications Sagi Tshori, Ehud Razin, Hovav Nechushtan 8 Association of Aminoacyl-tRNA Synthetases with Cancer Doyeun Kim, Nam Hoon Kwon, Sunghoon Kim 9 Pathogenic Implications of Human Mitochondrial Aminoacyl-tRNA Synthetases Hagen Schwenzer, Joffrey Zoll, Catherine Florentz, Marie Sissler 10 Role of Aminoacyl-tRNA Synthetases in Infectious Diseases and Targets for Therapeutic Development Varun Dewan, John Reader, Karin-Musier Forsyth 11 Flexizymes, Their Evolutionary History and Diverse Utilities Toby Passioura, Hiroaki Suga About the Author 1983–1986 Researcher, Genetic Eng. Center, KAIST, Korea 1991–1994 Post-doc, MIT, USA 1993–1994 Senior Scientist, Cubist Pharmaceuticals, USA 1994-2001 Associate Professor, Sung Kyun Kwan University, Korea 2001-present Professor, College of Pharmacy, Graduate Program in Bioinformatics , Genetic Engineering, Cancer Biology, Seoul National Univ. 1998-present Director, Center for Medicinal Protein Network and Systems Biology, Seoul National University 2008- Director, Information Center of Bio-pharmacological Network 2008- Director, Integrated Bioscience and Biotechnology Institute