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An Experimental Study of the Interaction Between Buprenorphine and Benzodiazepines

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£76.00 £72.20 £73.72 £75.24 £76.76 £78.28 £79.80 23 July 2026 11 August 2026 31 August 2026 19 September 2026 09 October 2026
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Price distribution over 79 days • 1 price levels

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79 days 0 20 40 59 79 £76 Days at Price

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Most common price: £76 (79 days, 100.0%)

Price range: £76 - £76

Price levels: 1 different prices over 79 days

Description

Forensic studies of deaths involving buprenorphine have shown that it is frequently associated with benzodiazepines and that asphyxia is consistently present. However, our postmortem studies conducted between 1997 and 2002 demonstrated that buprenorphine was clearly responsible for the fatal outcome in only 12% of cases. In adult rats, we confirmed the absence of effects or the presence of moderate and transient respiratory effects of high-dose buprenorphine alone and of five benzodiazepines alone at pharmacological doses. We validated, using HPLC-MS and GC-MS, specific and sensitive analytical methods to simultaneously identify and quantify buprenorphine, benzodiazepines, and their metabolites of interest in rat plasma samples. Our experimental data have thus highlighted the toxic role of flunitrazepam metabolites in the buprenorphine–benzodiazepine interaction process.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
18 March 2026
Listed Since
20 March 2026

Barcode

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