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Détection de la rigidité de la matrice extracellulaire et réponse cellulaire: Études comparatives sur les fibroblastes et les neurones

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£58.20 £57.97 £58.02 £58.07 £58.12 £58.17 £58.22 25 July 2026 15 August 2026 06 September 2026 27 September 2026 19 October 2026
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Description

Cet ouvrage se concentre sur les réponses à la rigidité de la matrice chez les neurones et les fibroblastes. Les exigences spécifiques en matière de rigidité de la matrice dans différents types de cellules ont été corrélées à la rigidité de leurs tissus natifs in vivo. Alors que les fibroblastes se propagent sur des zones plus vastes sur des substrats rigides que sur des substrats mous, les substrats mous stimulent l'élongation et la ramification des axones dans les neurones primaires. Dans nos études, nous avons décrit une voie de réponse à la rigidité spécifique à la fibronectine, présente à la fois dans les fibroblastes et les neurones. Bien que les neurones réagissent à la rigidité de la FN de manière opposée aux fibroblastes, nous suggérons que le mécanisme de détection de la rigidité de la FN est similaire et implique le recrutement de Fyn par RPTPα en fonction de la rigidité, puis la phosphorylation de la tyrosine p130Cas. Une fois phosphorylée, la p130Cas pourrait envoyer des signaux à diverses voies qui favorisent normalement la croissance et non la différenciation.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
09 March 2026
Listed Since
11 March 2026

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