£60.00

Lipogenesi della parete arteriosa

Biological Science

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Description

LIPOGENESI DELLA PARETE ARTERIOSA: REGOLAZIONE DELLA SUA ESPRESSIONE E ANOMALIE NELL'INSULINO-RESISTENZA E NEL DIABETE Abbiamo studiato l'espressione e la regolazione della lipogenesi nell'aorta e nel CMLV e determinato se essa sia modificata dall'insulino-resistenza e dal diabete. I ratti Zucker obesi (ZO), diabetici e Psammomys obesus accumulano più lipidi nelle loro aorte rispetto ai controlli. Tuttavia, l'espressione dei geni della lipogenesi e di quelli coinvolti nell'assorbimento degli acidi grassi non è aumentata. Un risultato simile è stato riscontrato in campioni di endarterectomie umane. L'ambiente adipogenico, il glucosio o l'insulina da soli stimolano moderatamente la lipogenesi solo nei CML di controllo Zucker, mentre nessun effetto è stato osservato nei CML di ZO. Abbiamo dimostrato che gli effetti del TO901317 sulla lipogenesi nei CMLV sono dovuti esclusivamente all'attivazione del recettore nucleare LXRα, mentre il PXR non ha alcun effetto. In conclusione, la lipogenesi non è aumentata nella parete arteriosa durante l'insulino-resistenza e il diabete.

Product Specifications

Format: paperback
ASIN: 6209546307
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 29 January 2026
Listed Since: 30 January 2026

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Lipogenesi della parete arteriosa

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