Proanthocyanidin against convulsion and cognitive impairment: Effects of proanthocyanidin against seizure, cognitive-impairment, and convulsion-induced neuro-oxidative Stress - Image 1

£74.99

LAP Lambert Academic Publishing Proanthocyanidin against convulsion and cognitive impairment: Effects of proanthocyanidin against seizure, cognitive-impairment, and convulsion-induced neuro-oxidative Stress

Name: Proanthocyanidin against convulsion and cognitive impairment: Effects of proanthocyanidin against seizure, cognitive-impairment, and convulsion-induced neuro-oxidative Stress
Brand: LAP Lambert Academic Publishing
Price: 74.99 GBP
Availability: InStock

Pharmacology

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Description

Convulsive status epilepticus is arguably one of the most debilitating neurological disorder, characterized by prolong episode of seizures. It is worthy of note that brain diseases pose the largest health, economic, and social capital burden worldwide of any disease group. This study has explored the potential effects of proanthocyanidin rich fraction (PRF) obtained from grape seed on the central nervous system particularly in convulsive status epilepticus (CSE) model. In this study, a significant brain and hippocampus atrophy, increased malondialdehyde concentration, increased hippocampus glial cells and granule count, exacerbated activities of acetylcholinesterase and increased indices of neuroinflammation following CSE induction are consistent with the hippocampus-dependent memory impairment observed observed among the convulsed mice. However, most of these aberrations including alteration of cholinergic neurotransmitters, astrogliosis, hippocampus toxicity, neuroinflammation, and neuronal necrosis were ameliorated following PRF treatment, a result similar to what was obtainable in the group treated with a standard drug, diazepam.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6209246133
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 07 November 2025
Listed Since: 22 November 2025

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LAP Lambert Academic Publishing Proanthocyanidin against convulsion and cognitive impairment: Effects of proanthocyanidin against seizure, cognitive-impairment, and convulsion-induced neuro-oxidative Stress

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