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Alterações genéticas em pacientes com cancro da tiróide do Vale da Caxemira: Corrida contra o cancro da tiróide

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£55.00 £52.25 £53.35 £54.45 £55.55 £56.65 £57.75 26 July 2026 09 August 2026 23 August 2026 06 September 2026 21 September 2026
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Price distribution over 58 days • 1 price levels

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58 days 0 15 29 44 58 £55 Days at Price

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Price levels: 1 different prices over 58 days

Description

O carcinoma da tiróide é a neoplasia maligna endócrina mais prevalente e representa 2% de todos os cancros humanos. Analisámos o exão 15 do gene BRAF e os exões 1 e 2 dos genes RAS em sessenta (60) amostras consecutivas de tecido da tiróide (tumor e tecido normal adjacente). No geral, foram encontradas mutações no BRAF em 25% (15 de 60) dos casos, afetando o códon 600 (valina para glutamina) e restritas apenas ao cancro papilar da tiróide, mas sem qualquer mutação no RAS. Analisámos 140 amostras de sangue de pacientes com cancro da tiróide para HRAS T81C e polimorfismo RET em comparação com 170 controles sem cancro. O gene TSHR foi encontrado hipermetilado em 25% (15 de 60) dos casos, com forte associação com níveis elevados de TSH. Concluímos que tanto os eventos mutacionais quanto a superexpressão do gene BRAF estão altamente implicados na patogênese do cancro da tiróide e que a superexpressão da proteína BRAF é independente do estado mutacional do BRAF. Os polimorfismos HRAS T81C e RET aumentam moderadamente o risco de cancro da tiróide. O nosso estudo mostrou uma alta implicação da metilação do gene TSHR e sua associação significativa com a mutação BRAF V600E em tumores da tiróide, retratando uma conexão positiva entre a via TSHR e a via MAP Kinase.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
31 May 2025
Listed Since
02 June 2025

Barcode

No barcode data available

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