£68.00

O papel da galectina-3 e da interleucina-22: O diagnóstico e a avaliação da atividade da doença na artrite reumatoide

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£68.00 £64.60 £65.96 £67.32 £68.68 £70.04 £71.40 27 June 2026 12 July 2026 27 July 2026 11 August 2026 27 August 2026

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Description

A Artrite Reumatoide (AR) é uma doença autoimune sistémica crónica que afecta principalmente as pequenas articulações. Embora existam atualmente biomarcadores estabelecidos que podem ser utilizados para diagnosticar a AR, tais como o FR e a ACPA, continua a haver necessidade de novos biomarcadores para melhorar a precisão e a deteção precoce da AR, uma vez que se trata de uma doença complexa e heterogénea, com uma vasta gama de sintomas e de evolução da doença. Esta investigação teve como objetivo estudar o valor diagnóstico da galectina-3 e da interleucina-22 como biomarcadores ideais para o diagnóstico da AR, para além de estudar o seu papel na avaliação da atividade da AR. Os níveis de gal-3 e IL-22 foram positivamente correlacionados com os índices de atividade da doença CDAI, DAS-28 ESR e DAS-28 CRP. Relativamente aos valores de diagnóstico da gal-3 e da IL-22 na deteção da AR, as curvas de características de funcionamento do recetor (ROC) revelaram que o melhor valor de corte de diagnóstico da gal-3 urinária era ≥ 2,4 ng/ml, com 89% de sensibilidade, 91% de especificidade e uma área sob a curva (AUC) = 0,893. Enquanto o melhor valor de corte de diagnóstico de IL-22 foi ≥ 26,9 pg/ml, com 83% de sensibilidade, 75% de especificidade e uma área sob a curva (AUC) = 0,838.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
12 December 2023
Listed Since
13 December 2023

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