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Studio della genetica cito-molecolare di alcuni pazienti iracheni affetti da ALL: Studio delle alterazioni genetiche e del livello di danno al DNA in alcuni pazienti iracheni affetti da ALL

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£56.00 £53.20 £54.32 £55.44 £56.56 £57.68 £58.80 11 August 2026 19 August 2026 28 August 2026 06 September 2026 15 September 2026
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Description

La leucemia linfoblastica acuta (ALL) è il tumore più comune in età pediatrica e, sebbene di elevata guarigione, la recidiva rimane una delle principali cause di prevalenza di ALL nei bambini. Con l'aumentare dell'età, la frequenza di alterazioni genetiche associate a un esito sfavorevole, come BCR-ABL1, è più comune. Ad eccezione degli inibitori della tirosin-chinasi (TKI), le terapie attuali non mirano a specifiche alterazioni genetiche e sono associate a tossicità a breve e a lungo termine che limitano la possibilità di aumentare la dose. È quindi importante determinare le alterazioni genetiche della leucemogenesi, per gestire le strategie terapeutiche dei pazienti affetti da ALL. Questi studi evidenziano inoltre che. Circa il 70-75% dei pazienti affetti da ALL presenta un'alterazione cromosomica rilevabile mediante cariotipo, FISH o tecniche molecolari. Sebbene questi riarrangiamenti siano eventi iniziali importanti nella leucemogenesi e siano ampiamente utilizzati negli algoritmi di diagnosi e di stratificazione del rischio, non sono sufficienti a spiegare completamente la leucemogenesi. È ormai noto che la maggior parte dei casi di ALL è caratterizzata da mutazioni di sequenza distinte.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
21 July 2023
Listed Since
22 July 2023

Barcode

No barcode data available

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