Preparation of Some Radiolabeled Phosphonates for Bone Imaging - Image 1

£67.00

LAP Lambert Academic Publishing Preparation of Some Radiolabeled Phosphonates for Bone Imaging

Name: Preparation of Some Radiolabeled Phosphonates for Bone Imaging
Brand: LAP Lambert Academic Publishing
Price: 67.0 GBP
Availability: InStock

Chemistry

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Description

This study is focused on the synthesis of two bisphosphonate derivatives, 1-hydroxy-2-(3-pyridyl) ethylidene bisphosphonic acid monosodium (sod. risedronate) and 1-hydroxy-2-(2-pyridyl) ethylidene bisphosphonic acid monosodium (HPEBP) from corresponding nitrile. The labeling of two compounds was studied with technetium-99m using two different reducing agents (SnCl2.2H2O and NaBH4) where NaBH4 gave a stable complex and high radiochemical yield more than SnCl2.2H2O. The radiochemical yield of 99mTc-risedronate and 99mTc-HPEBP were 99.2 ± 0.6 and 95.5 ± 3.5%, respectively, which more than that of the SnCl2.2H2O method (84.5 ± 3.5 and 83.9 ± 3%, respectively). Both radiolabeled complexes showed in vitro stability, up to 6 hours. The in vivo biodistribution studies, performed in mice, show highly selective uptake of both labeled compounds in the skeletal system and rapid elimination via the urinary pathway. The maximum value of the bone uptake after 30 min was 30.25 ± 3 and 31 ± 2 % ID/organ for risedronate and HPEBP, respectively.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6204738801
Category: Books > Subjects > Science, Nature & Maths > Chemistry
Domain: Amazon UK
Release Date: 24 January 2022
Listed Since: 18 February 2022

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LAP Lambert Academic Publishing Preparation of Some Radiolabeled Phosphonates for Bone Imaging

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