Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide - Image 1

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LAP Lambert Academic Publishing Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide

Name: Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide
Brand: LAP Lambert Academic Publishing
Price: 47.0 GBP
Availability: InStock

Chemistry

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The research involves synthesis of some new aminoacetylenic derivatives of phthalimide. The phthalimide in this study served as starting material and was converted to the corresponding potassium salt through reaction with potassium hydroxide. The alkylation of the imide salt with the propargyl bromide afforded the desired N-propynylphthalimide (A1). The Mannich reaction (three componenets in one pot reaction) was carried out by using the N-propynylphthalimide (A1), formaldehyde, benzaldehyde and some of its derivatives, as well as morpholine or piperidine which are taken as secondary amines, in the presence of peroxide free dioxane and a catalytic amount of cuprous chloride under various basic, acidic, solvent and temperature conditions, resulted in formation of a novel aminoacetylenic Isoindoline-1,3-dione derivatives (A2-A12).

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6200499683
Category: Books > Subjects > Science, Nature & Maths > Chemistry
Domain: Amazon UK
Release Date: 24 December 2019
Listed Since: 17 January 2020

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LAP Lambert Academic Publishing Synthesis & Study Biological Activity of New Phthalimide Derivatives: Study the biological activity of new Mannich bases derived from phthalimide

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