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Genómica comparativa y estrategias de diseño de fármacos: Estudio basado en enfoques bioinformáticos de los parásitos de la malaria

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£54.00 £51.30 £52.38 £53.46 £54.54 £55.62 £56.70 01 August 2026 19 August 2026 06 September 2026 24 September 2026 13 October 2026
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Description

La malaria es una amenaza para la humanidad y responsable de millones de casos de morbilidad y mortalidad en todo el mundo. El parásito Plasmodium es el responsable de causar la enfermedad. Este trabajo investiga y revela la información oculta en el genoma del parásito mediante el análisis comparativo del genoma y el estudio del sesgo en el uso de codones. Se ha comprobado la posibilidad de utilizar proteínas de superficie variables como objetivo común para los fármacos en las especies de Plasmodium que infectan al ser humano, y se ha descubierto que las proteínas de superficie variables no pueden utilizarse como objetivo común para los fármacos debido a la existencia de diferencias secuenciales y estructurales tanto a nivel del genoma como del proteoma. En este trabajo también se utiliza la información de la red metabólica para identificar nuevas dianas farmacológicas. Además, se utilizaron otros enfoques in silico, como el modelado molecular, la generación de modelos farmacóforos 3D basados en estructuras, el cribado virtual y el acoplamiento, etc., para encontrar los prototipos de fármacos.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
14 September 2025
Listed Since
15 September 2025

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