Transdermal patches of anti-diabetic drugs - Image 1

£58.00

LAP Lambert Academic Publishing Transdermal patches of anti-diabetic drugs

Name: Transdermal patches of anti-diabetic drugs
Brand: LAP Lambert Academic Publishing
Price: 58.0 GBP
Availability: InStock

Pharmacology

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Description

ABSTRACT The transdermal drug delivery systems were developed to overcome the limitations associated with oral administration and to mimic the effects of intravenous infusion. The solubility of poorly soluble anti-diabetic drugs, glimepiride and glibenclamide was enhanced by preparing solid dispersion using beta cyclodextrin as a carrier in the ratio of 1:2. The solid dispersions were evaluated by solubility study, scanning electron microscopy and X-ray diffraction studies which indicated the conversion of drug into amorphous form. The permeability of saxagliptin was enhanced by employing 4% sodium lauryl sulphate by co-surfactant method. The above mentioned physically modified drugs were formulated as transdermal delivery systems using hydroxy propyl methyl cellulose, ethyl cellulose and chitosan as rate controlling polymers. The formulated transdermal drug delivery systems were evaluated for physico-chemical properties and in vitro diffusion study and in vivo studies. Based on the evaluation criteria F4(glimepiride), Q4 (glibenclamide) and S4 (saxagliptin) which were on par with the aim and objective of the present investigation were optimized.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6200242372
Category: Books > Subjects > Health, Family & Lifestyle > Medical & Healthcare Practitioners > Other Branches of Medicine > Pharmacology
Domain: Amazon UK
Release Date: 28 April 2022
Listed Since: 23 May 2022

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LAP Lambert Academic Publishing Transdermal patches of anti-diabetic drugs

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