Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS: Bioanalysis of Immunosuppressant Drugs - Image 1

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LAP Lambert Academic Publishing Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS: Bioanalysis of Immunosuppressant Drugs

Name: Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS: Bioanalysis of Immunosuppressant Drugs
Brand: LAP Lambert Academic Publishing
Price: 49.0 GBP
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Chemistry

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Description

Due to narrow therapeutic indices of immunosuppressants and highly variable pharmacokinetics, therapeutic drug monitoring is necessary to individualize immunosuppressant dosage following organ transplantation. Until recently, monitoring was performed primarily using immunoassays; however, there is an increasing shift to HPLC coupled with MS/MS, due to its greater sensitivity and specificity. Online sample clean-up with either a single analytical column or with 2D chromatography significantly reduces manual handling and is essential to minimize matrix effects and maximize specificity. Coupled with rapid chromatography, it allows simultaneous analysis of the major immunosuppressants, with high sample throughput. Thus, LC–MS/MS is an attractive and versatile technique that facilitates rapid development of analytical methods, including new immunosuppressants as they become approved for clinical use.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6139821355
Category: Books > Subjects > Science, Nature & Maths > Chemistry
Domain: Amazon UK
Release Date: 19 April 2018
Listed Since: 15 May 2018

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LAP Lambert Academic Publishing Quantitative Determination of Immunosuppressant Drugs by LC-MS/MS: Bioanalysis of Immunosuppressant Drugs

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