The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects - Image 1

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LAP Lambert Academic Publishing The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects

Name: The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects
Brand: LAP Lambert Academic Publishing
Price: 49.0 GBP
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Biological Science

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Description

The sodium-coupled phosphate transporter NaPi-IIa is the main cellular carrier accomplishing kidney phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through the Na+/K+ ATPase. Energy starvation is sensed by the AMPK, a serine/threonine kinase stimulating several cellular mechanisms increasing energy production and limiting energy consumption. AMPK provides a critical link between energy metabolism and cellular transport. The aging suppressor Klotho, a transmembrane protein, is a protease and hormone has been shown to exert a profound effect on phosphate metabolism, aging, and lifespan. Additionally, the enzymes SGK1, mTOR, Akt/PKB and Nedd4-2 are of critical importance for a wide variety of functions including bone mineralization and energy metabolism. The present book explores the mechanisms of phosphate homeostasis and the role of AMPK, Klotho, SGK1, mTOR, Akt/PKB and Nedd4-2 in the regulation of NaPi-IIa activity.

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6139457777
Category: Books > Subjects > Science, Nature & Maths > Biological Sciences > Biological Science
Domain: Amazon UK
Release Date: 14 March 2019
Listed Since: 09 April 2019

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LAP Lambert Academic Publishing The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects

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LAP Lambert Academic Publishing The cotransporter NaPi-IIa: enzyme-dependent activity regulation: Cellular mechanisms and health effects

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