5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents: Synthesis of New Substituted Anticancer Agent Part I - Image 1

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LAP Lambert Academic Publishing 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents: Synthesis of New Substituted Anticancer Agent Part I

Name: 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents: Synthesis of New Substituted Anticancer Agent Part I
Brand: LAP Lambert Academic Publishing
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Chemistry

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Description

In search of new anticancer agents we have reported the synthesis of some 1,3,4-thiadiazoles. While designing target molecules, we studied some reported HDAC (Histone deacetylases) inhibitor and from that we have used some fragments to design new target molecules. The reaction was monitored by TLC using suitable mobile phase and also determined the melting point of the Thiadiazole analogues. It is found that they were different from each other’s. Furthermore also characterized and confirmed by IR, 1H-NMR, and Mass spectral. For anticancer activity, all the selected compounds were submitted to NCI (National Cancer Institute) for in vitro anticancer activity. Primary in vitro one dose anticancer assay was performed in full NCI 60 cell panel in accordance with the protocol of the NCI, USA. The compound 5(a) and (6b) showed good activity against the all cancer cell lines at NCI, USA

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 6139448050
Category: Books > Subjects > Science, Nature & Maths > Chemistry
Domain: Amazon UK
Release Date: 04 February 2019
Listed Since: 04 March 2019

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LAP Lambert Academic Publishing 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents: Synthesis of New Substituted Anticancer Agent Part I

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LAP Lambert Academic Publishing 5-Aryl 1,3,4 -Thiadiazole Derivatives As Potential Anticancer Agents: Synthesis of New Substituted Anticancer Agent Part I

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