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ÉDITIONS UNIVERSITAIRES EUROPÉENNES Purification et caractérisation des phospholipase du venin de scorpion

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£48.00 £45.60 £46.56 £47.52 £48.48 £49.44 £50.40 12 August 2026 20 August 2026 28 August 2026 05 September 2026 14 September 2026
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Description

Les sPLA 2 sont des enzymes hydrolysant les phospholipides en sn-2 libérant un acide gras et un lysophospholipide. Elles contrôlent la production des ecosanoïdes, des chimiokines et les molécules d’adhérence importants pour le fonctionnement cellulaires. Le cancer est considéré comme l'un des principales causes de décès dans le monde. Les thérapies traditionnelles représentent les seuls moyens de lutte et ont beaucoup d’effets secondaires. De ce fait, la recherche s’est orientée vers les agents biologiques. A partir des venins de scorpions, plusieurs molécules bloquant la croissance et la propagation des cellules cancéreuses ont été révélées. Ce travail a permis la purification de deux nouvelles sPLA 2 groupe III Hemilipin et Hemilipin2 jusqu'à leur homogénéité à partir du venin du scorpion iranien Hemiscorpius lepturus. Ce sont deux enzymes hétérodimériques d'une masse moléculaire de 15Kda. Elles présentent un potentiel antiangiogènique par l'inhibition de la migration, l’adhésion et la propagation in vivo et ex vivo. Les activités enzymatique et antiangiogènique sont indépendantes et la petite sous-unité est responsable de ces effets.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
04 April 2019
Listed Since
23 May 2019

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