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OmniScriptum Transporteurs ABC de type MDR chez Bacillus subtilis: Rôle et régulation de l'expression de leur gène de structure (Omn.Univ.Europ.)

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Description

Bacillus subtilis est une bactérie non pathogène à Gram positif, vivant principalement dans le sol mais que l'on peut également rencontrer dans des écosystèmes marins ou dans le tractus digestifs d'animaux. Ayant à survivre dans des conditions environnementales très variables elle possède une grande capacité s'adapter. Ainsi, un grand nombre de transporteurs ABC (ATP Binding Cassette) participent à la survie des bactéries en assurant notamment l'import de nutriments ou l'export de composés toxiques au travers de la membrane cellulaire. L'analyse du génome de Bacillus subtilis a permis de répertorier l'ensemble des transporteurs ABC et nous nous sommes intéressés à trois membres d'une même famille présentant de fortes similarités avec des prototypes de transporteurs ABC de type MDR (Multi Drug Resistance): MDR1, une glycoprotéine-P humaine et LmrA de Lactococcus lactis, premier transporteur de ce type à avoir été mis en évidence chez une bactérie. Cette thèse porte donc sur l'étude fonctionnelle des transporteurs YvcC , YwjA et YgaD ainsi que sur l'étude de la régulation de l'expression de leurs gènes.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
03 May 2011
Listed Since
05 May 2011

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