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OmniScriptum Potentiel thérapeutique de la décorine dans la réparation artérielle: Applications pré-cliniques dans l'athérosclérose et la resténose post-angioplastie (Omn.Univ.Europ.)

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Description

L'athérosclérose et la resténose post-angioplastie représentent deux pathologies vasculaires où la réparation artérielle joue un rôle central dans leur développement. Au cours du processus de réparation induit après lésion, le déséquilibre de la balance entre l'inflammation et la fibrose peut causer une hyperplasie intimale et un remodelage géométrique inapproprié de l'artère. La décorine est un petit protéoglycane exprimé dans les plaques athéroscléreuses avancées ainsi que dans les lésions avancées de resténose. Elle participe à la régulation de la fibrillogenèse du collagène, de la bio- disponibilité du TGF-?1, de la croissance et de la migration cellulaire. Des précédents travaux ont utilisé la décorine comme agent anti-fibrotique dans des modèles de fibrose pulmonaire et rénale. Dans le présent travail, nous évaluons le potentiel thérapeutique de la surexpression de la décorine sur la réparation artérielle dans deux modèles animaux de réparation artérielle: l'athérosclérose et la resténose post-angioplastie.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
07 November 2010
Listed Since
10 November 2010

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