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OmniScriptum Neuromodulation des neurones monoaminergiques et cycle veille-sommeil: Approches électrophysiologique et pharmacologique chez le rat vigile (Omn.Univ.Europ.)

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Description

Les neurones noradrénergiques (NA) du locus coeruleus et sérotonergiques (5-HT) du raphé dorsal sont fortement impliqués dans la régulation des états d'éveil et de sommeil. Ils ont une activité tonique au cours de l'éveil, diminuent leur décharge au cours du sommeil lent et sont silencieux au cours du sommeil paradoxal (sommeil du rêve). Nécessaire à l'endormissement et à la survenue du rêve, l'inactivation des neurones NA et 5-HT fait ici l'objet de différentes hypothèses testées sur un nouveau modèle expérimental de rat non anesthésié en contention stéréotaxique. Les résultats obtenus montrent que le GABA, neuromédiateur inhibiteur majeur du SNC, est responsable de la diminution puis de l'arrêt d'activité des neurones NA et 5-HT au cours du sommeil lent et du sommeil paradoxal. Plusieurs populations de neurones GABAergiques seraient impliquées dans l'inactivation des neurones NA et 5-HT, l'une localisée dans l'aire préoptique latérale et ventrolatérale serait mise en jeu au cours du sommeil lent, l'autre formée notamment de neurones GABAergiques de la substance grise péri- aqueducale serait mise en jeu au cours du sommeil paradoxal.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
23 September 2010
Listed Since
24 September 2010

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