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Editions Universitaires Europeennes NEUROPEPTIDES ET ANTIDÉPRESSEURS: RÔLE DE LA SUBSTANCE P ET DU BRAIN-DERIVED NEUROTROPHIC FACTOR DANS LE MÉCANISME D'ACTION DES ANTIDÉPRESSEURS SÉROTONINERGIQUES

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£66.00 £62.70 £64.02 £65.34 £66.66 £67.98 £69.30 25 July 2026 09 August 2026 24 August 2026 08 September 2026 23 September 2026
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Description

La substance P et le Brain-Derived Neurotrophic Factor (BDNF) sont deux neuropeptides excitateurs du cerveau qui seraient impliqués dans le contrôle des émotions et le mécanisme d'action des antidépresseurs. Ce travail a eu pour objectif de préciser leur rôle respectif sur la neurotransmission sérotoninergique basale ou stimulée par un antidépresseur de type Inhibiteur de la Recapture Sélectif de la Sérotonine (IRSS). Dans une première partie, nous avons montré que l'activation des récepteurs NK1 par l'injection intra-raphé de substance P, diminue la neurotransmission sérotoninergique corticale alors que l'inactivation de ces récepteurs, potentialise les effets neurochimiques d'un IRSS. Dans une seconde partie, nous avons montré que la baisse des concentrations cérébrales de BDNF, provoque une diminution de l'activité du transporteur 5-HTT de la sérotonine en rapport avec une atténuation de l'efficacité neurochimique d'un IRSS dans l'hippocampe. Cet ouvrage expose les bases bibliographiques et expérimentales qui permettent de comprendre comment deux neuropeptides excitateurs peuvent interférer différemment sur la neurotransmission sérotoninergique centrale.

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