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OmniScriptum Système biomimétique d'intermédiaires de transport tubulaires: Etude quantitative (Omn.Univ.Europ.)

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Description

Les tubes de membrane sont omniprésents dans les cellules vivantes eucaryotes. Ce sont des structures très dynamiques qui permettent en particulier la communication entre les différents compartiments membranaires de la cellule. Pour comprendre les mécanismes impliqués dans le trafic intracellulaire, il paraît essentiel d'isoler le rôle des différents constituants impliqués. Dans ce but, j'ai utilisé un système minimal qui permet de mimer in vitro les différentes étapes d'extraction, de croissance et d'arrêt de nanotubes de membrane avec des éléments purifiés ou artificiels (kinésines, microtubules, vésicules géantes unilamellaires). La confrontation des résultats expérimentaux avec ceux obtenus par une analyse théorique du système effectuée en parallèle, a permis de caractériser de façon complète et quantitative ces différentes étapes. Ce système biomimétique, bien que simplifié, permet d'apporter une nouvelle approche du trafic intracellulaire, en proposant des mécanismes physiques qui sont souvent masqués, dans les cellules, par des mécanismes moléculaires.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
16 June 2010
Listed Since
22 June 2010

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