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ÉDITIONS UNIVERSITAIRES EUROPÉENNES EFFETS DES ANTIDÉPRESSEURS SUR DES MODÈLES MURINS: Etude de la variabilité et de la taille de l'effet des antidépresseurs sur des modèles comportementaux et neurobiologiques (Omn.Univ.Europ.)

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£80.00 £76.00 £77.60 £79.20 £80.80 £82.40 £84.00 25 July 2026 08 August 2026 22 August 2026 05 September 2026 20 September 2026
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Description

Ce travail a été réalisé in vivo chez la Souris sur des modèles comportementaux (test de la nage forcée, FST et test de suspension caudale, TST) et neurobiochimique (microdialyse intracérébrale). Les études comportementales ont exploré les facteurs supposés de variabilité des souris (souche, sexe, âge) afin de déterminer quels paramètres modifier pour sensibiliser les tests. La souris mâle de fond génétique Swiss âgée de 4 semaines est celle qui est la mieux adaptée à nos conditions expérimentales pour détecter un effet antidépresseur. En microdialyse, nous avons recherché une relation entre la pharmacodynamie (variations des temps d’immobilité dans le FST) et les concentrations extracellulaires de sérotonine ([5-HT]ext) et de noradrénaline ([NA]ext) corticales.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
06 July 2010
Listed Since
06 May 2010

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