Springer Anesthesia and Neurotoxicity

This book, written by leading Japanese experts in the field, describes the latest findings on the neurotoxicity of anesthetics for the developing brain, postoperative delirium and cognitive dysfunction. It describes the risk factors for postoperative cognitive dysfunction in elderly surgical patients. Since the number of elderly patients undergoing surgery and anesthesia continues to increase, it is important to improve our understanding of the risks and mechanisms of postoperative delirium and cognitive dysfunction, potential ways to prevent or alleviate them and the public health implications. Recently, it has been shown that using anesthetics on the developing brain causes apoptotic neurodegeneration and persistent learning/memory deficits later in life. Anesthesiologists need more information on this mechanism in the human brain. The negative effects of anesthesia and surgery on the nervous system have attracted attention lately; this book provides physicians, researchers, and postdocs with invaluable information on this topic. Review “Anesthesia and Neurotoxicity – a unique synthesis of basic science and clinical research – is concerned with the neurotoxic effects of anesthetic drugs. It is a concise, up-to-date review of the literature and could be a useful reference for anesthesia care providers who may have to allay their patients’ concerns about the potential harmful effects of general anesthesia.” (O. Predescu, Canadian Journal of Anesthesia/Journal canadien d'anesthésie, Vol. 65 (10), October, 2018) “This book covers a wide range of anesthesia and neurotoxicity topics: from developmental neurotoxicity to POD and POCD, from animal studies to clinical evidence, from diagnosis of neurotoxicity to prevention and treatment approaches, and from symptoms to the underlying mechanisms.” (Xiaowen Bai, Anesthesia & Analgesia, Vol. 127 (2), August, 2018) About the Author Department of Anesthesiology and Critical Care Medicine, Hokkaido University School of Medicine.