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EAE Editorial Academia Espanola Efecto de la suplementación de metionina sobre el estrés oxidativo: y de la edad sobre la presencia de ADN mitocondrial en el ADN nuclear, en rata Wistar

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Description

La restricción dietética es la manipulación experimental mejor conocida capaz de incrementar la longevidad máxima. La restricción de un único aminoácido, la metionina, puede incrementar la longevidad máxima y reducir tanto la producción mitocondrial de radicales libres de oxígeno como el estrés oxidativo. El contenido de metionina en las dietas occidentales excede la cantidad diaria recomendada, por lo que dichas poblaciones están sometidas a suplementación de metionina. La suplementación de metionina genera una gran toxicidad en diversos órganos, sin embargo se desconoce el mecanismo por el cual se produce este daño. Además, los radicales libres tienen la capacidad de generar fragmentos de ADN mitocondrial. Se ha propuesto que estos fragmentos serían capaces llegar al núcleo e integrarse en el ADN de este orgánulo, de modo que su acumulación podría alterar la información codificada en este último, lo que podría contribuir a la formación de células tumorales y al proceso de envejecimiento. Para intentar aclarar estas cuestiones se realizaron una serie de experimentos que se detallan en este libro, así como los resultados y las conclusiones que se pueden extraer de los mismos.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
12 January 2012
Listed Since
14 January 2012

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