Genetic Immunization & Cytokine Immunomodulation: Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes - Image 1

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LAP Lambert Academic Publishing Genetic Immunization & Cytokine Immunomodulation: Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes

Name: Genetic Immunization & Cytokine Immunomodulation: Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes
Brand: LAP Lambert Academic Publishing
Price: 50.0 GBP
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In chronic parasitic infections, the interplay between the host and the parasite suggests immuno-suppressive mechanisms developed by the parasite. Echinococcus granulosus, a tiny tapeworm that among other helminthes, favors the induction of T helper type 2 responses which are less severe and less destructive than T helper type 1 responses. This study aimed at exploring the immune response generated in BALB/c mice using genetic immunization technology. Immuno-modulation by the co-delivery of different cytokine genes (IFN-γ, IL-12, IL-4) was also investigated. Immunization by antigen B or its second subunit (EgAgB8/2) revealed dominated T helper type 2 cytokine response, IgG3 humoral response, low splenocyte cell proliferation, and low CD8+ cell count. However, restored CD8+ cell count, high splenocyte cell proliferation, and high expression of IFN-γ cytokine in IFN-γ gene co-immunized mice indicates the efficiency of cytokine gene immuno-modulation in skewing the response toward T helper type 1. About the Author Biology B.Sc, Biotechnology M.Sc., Molecular Medicine PhD Candidate (Taiwan International Graduate Program), National Yang-Ming University (Taipei Taiwan),Institute of Biomedical Sciences - Academia Sinica (Taipei, Taiwan).

Product Specifications

Brand: LAP Lambert Academic Publishing
Format: paperback
ASIN: 3847312391
Category: Books > Subjects > Reference > Words, Language & Grammar
Domain: Amazon UK
Release Date: 16 December 2011
Listed Since: 21 December 2011

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LAP Lambert Academic Publishing Genetic Immunization & Cytokine Immunomodulation: Immune Response in Mice Genetically Immunized with Echinococcus granulosus AgB2 in Combination with Cytokine Genes

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