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EAE Editorial Academia Espanola Plantas Argentinas Como Fuente de Metabolitos Antifúngicos: Aislamiento y Modificaciones Semi-sintéticas de Compuestos Antifúngicos Presentes en Especies del Género Polygonum

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£60.00 £57.00 £58.20 £59.40 £60.60 £61.80 £63.00 11 August 2026 19 August 2026 28 August 2026 06 September 2026 15 September 2026
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36 days 0 9 18 27 36 £60 Days at Price

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Price levels: 1 different prices over 36 days

Description

El descubrimiento de nuevos compuestos antifúngicos es una necesidad urgente debido al incremento en las últimas décadas de pacientes inmunocomprometidos y a la ineficacia y toxicidad de las drogas existentes en uso clínico. El reino vegetal representa un enorme reservorio de moléculas novedosas y particularmente la Argentina tiene una gran diversidad vegetal poco explorada en cuanto a su actividad antifúngica. Utilizando un criterio etnofarmacológico se seleccionaron 10 especies vegetales, de las cuales Polygonum acuminatum y P. persicaria resultaron las más activas frente a un panel de hongos oportunistas y patogénicos para el humano. Del fraccionamiento bioguiado de ambas especies se aislaron sesquiterpenos con esqueleto drimano y flavonoides del tipo flavanonas y chalconas como agentes antifúngicos activos. Ambos tipos de compuestos fueron utilizados como marcadores químicos con el fin de delimitar desde un punto de vista quimiotaxonómico a la sección Persicaria del género Polygonum. Se prepararon derivados y análogos de poligodial por semisíntesis y por biotransformaciones, con los cuales se pudo realizar un interesante estudio de relación estructura-actividad.

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