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LAP Lambert Academic Publishing the role of cytokines on synaptic plasticity in the dentate gyrus

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Description

Pro-inflammatory cytokines have been implicated in a wide range of central nervous system (CNS) disorders, including trauma, ischemia, multiple sclerosis and Alzheimer's disease. Tumour necrosis factor- (TNF-) and interleukin-18 (IL-18), both pro-inflammatory cytokines, have previously been shown to attenuate long-term potentiation (LTP), a proposed model for learning and memory. This study investigated the mechanisms underlying the TNF- and IL-18 mediated inhibition of LTP. Initial experiments consolidate evidence on inducing LTP in the dentate gyrus of the hippocampus. Subsequent experiments consolidate evidence that TNF- and IL-18 can impair LTP in the dentate gyrus.

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
19 July 2011
Listed Since
22 July 2011

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