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ACADEMIQUES Fonctionnalisation de la 4- Thiazolinethione: Application à la synthèse des colorants Rhodacyanines par activation micro-ondes

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Description

Résumé : La lutte contre le paludisme occupe une place importante dans la recherche thérapeutique mondiale. Les rhodacyanines qui sont des cations à électrons π délocalisés (DLCs) se sont révélés comme étant des inhibiteurs potentiels contre le paludisme et les cellules cancéreuses. Compte-tenu de l’importance de cette famille des composés à propriétés pharmacologiques importantes, il nous a paru intéressant de synthétiser des rhodacyanines analogues en utilisant l’activation micro-ondes, technologie propre et performante. Notre choix s’est porté sur la 4- thiazolinethione connue pour son potentiel pharmacodynamique très large, antimalaria, antifongique, antibactérien, antispasmodique et antiviral. La fonctionnalisation de la 4- thiazolinethione, comme molécule chef de file permet la synthèse des rhodacyanines analogues. Mots clés : 4-Thiazolinethione, Rhodanine, Rhodacyanines , Irradiation micro-ondes, Cation DLCs, Réaction de Vilsmeier-Haack, antitumoral, antimalaria, Iminothiazolidinone

Product Specifications

Format
paperback
Domain
Amazon UK
Release Date
21 September 2013
Listed Since
24 October 2013

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